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The Carriers investigates a common but still little-known genetic condition and its life-altering consequences. Anne Skomorowsky reveals how fragile X syndrome afflicts families across generations, telling the stories of the mothers and grandparents of fragile X patients and considering how genes interact with family dynamics.

Fragile X syndrome.

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Human genetics --- Neuropathology --- Fragile X syndrome.

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The present book is an in-depth synopsis of recent advances in the fragile X field. The fragile X syndrome (FXS) is the most common form of inherited mental retardation, and the molecular-genetic basis of this syndrome has been the subject of extensive experimental scrutiny over the last two decades. This book covers the spectrum of current FXS research, ranging from Drosophila model systems via mouse models to clinical and psychiatric aspects. The volume also provides updates on FXS-related diseases such as the fragile X-associated tremor/ataxia syndrome. Significant progress in recent years, as highlighted here by some of the most eminent researchers in the field, are grounds for optimism that successful therapeutical approaches may be feasible in the not too distant future.

Fragile X syndrome. --- Fragile X syndrome -- Animal models. --- Fragile X syndrome --- Mental Retardation, X-Linked --- Sex Chromosome Disorders --- Investigative Techniques --- Chromosome Disorders --- Mental Retardation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Diseases, X-Linked --- Heredodegenerative Disorders, Nervous System --- Neurobehavioral Manifestations --- Genetic Diseases, Inborn --- Congenital Abnormalities --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Neurologic Manifestations --- Nervous System Diseases --- Diseases --- Fragile X Syndrome --- Models, Animal --- Medicine --- Biology --- Health & Biological Sciences --- Pediatrics --- Cytology --- Animal models --- X-linked mental retardation. --- XLMR (Disease) --- fra(X) syndrome --- Life sciences. --- Human genetics. --- Gene therapy. --- Molecular biology. --- Cell biology. --- Stem cells. --- Neurobiology. --- Life Sciences. --- Cell Biology. --- Human Genetics. --- Molecular Medicine. --- Stem Cells. --- Gene Therapy. --- Intellectual disability --- X chromosome --- Syndromes --- X-linked mental retardation --- Abnormalities --- Cytology. --- Medicine. --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Neurosciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Genetics --- Heredity, Human --- Physical anthropology --- Cell biology --- Cellular biology --- Cytologists --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medical genetics. --- Neurosciences. --- Medical Genetics. --- Biomedical Research. --- Neuroscience. --- Stem Cell Biology. --- Clinical Genetics. --- Research. --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Biological research --- Biomedical research --- Clinical genetics --- Heredity of disease --- Human genetics --- Genetic disorders --- Genetic aspects

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In The Fragile X-Associated Tremor Ataxia Syndrome (FXTAS), the editors present information on all aspects of FXTAS, including clinical features and current supportive management, radiological, psychological, and pathological findings, genotype-phenotype relationships, animal models and basic molecular mechanisms. Genetic counseling issues are also discussed. The book should serve as a resource for professionals in all fields regarding diagnosis, management, and counseling of patients with FXTAS and their families, as well as presenting the molecular basis for disease that may lead to the identification of new markers to predict disease risk and eventually lead to target treatments.

Chromosome abnormalities. --- Fragile X syndrome. --- Tremor -- Genetic aspects. --- Tremor -- Therapy. --- Tremor. --- Fragile X syndrome --- Tremor --- Chromosome abnormalities --- Fragile X Syndrome --- Chromosome Fragility --- Genetics --- Ataxia --- Chromosome Fragile Sites --- Sex Chromosome Disorders --- Chromosomal Instability --- Dyskinesias --- Mental Retardation, X-Linked --- DNA Sequence, Unstable --- Biology --- Chromosome Disorders --- Biological Science Disciplines --- Genome Components --- Genomic Instability --- Neurologic Manifestations --- Chromosome Aberrations --- Heredodegenerative Disorders, Nervous System --- Genetic Diseases, X-Linked --- Mental Retardation --- Congenital Abnormalities --- Pathologic Processes --- Mutation --- Genetic Diseases, Inborn --- Natural Science Disciplines --- Neurobehavioral Manifestations --- Genetic Phenomena --- Nervous System Diseases --- Signs and Symptoms --- Genome --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Diseases --- Pathological Conditions, Signs and Symptoms --- Genetic Structures --- Genetic Variation --- Disciplines and Occupations --- Phenomena and Processes --- Pediatrics --- Pathology --- Medicine --- Health & Biological Sciences --- Genetic aspects --- fra(X) syndrome --- Medicine. --- Human genetics. --- Molecular biology. --- Neurosciences. --- Biomedicine. --- Human Genetics. --- Molecular Medicine. --- Syndromes --- X-linked mental retardation --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Heredity, Human --- Physical anthropology --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Mental retardation --- Mental Retardation. --- Mental retardation. --- Intellectual Disability. --- Mental Retardation --- Intellectual disability --- Intellectual disability. --- Deficiency, Mental --- Intellectual Development Disorder --- Mental Deficiency --- Mental Retardation, Psychosocial --- Disability, Intellectual --- Idiocy --- Retardation, Mental --- Deficiencies, Mental --- Development Disorder, Intellectual --- Development Disorders, Intellectual --- Disabilities, Intellectual --- Disorder, Intellectual Development --- Disorders, Intellectual Development --- Intellectual Development Disorders --- Intellectual Disabilities --- Mental Deficiencies --- Mental Retardations, Psychosocial --- Psychosocial Mental Retardation --- Psychosocial Mental Retardations --- Retardation, Psychosocial Mental --- Retardations, Psychosocial Mental --- Abnormalities, Multiple --- Cockayne Syndrome --- Cri-du-Chat Syndrome --- De Lange Syndrome --- Fragile X Syndrome --- Laurence-Moon Syndrome --- Prader-Willi Syndrome --- Rubinstein-Taybi Syndrome --- Rett Syndrome --- Angelman Syndrome --- Williams Syndrome --- Persons with Mental Disabilities --- Brain Diseases, Metabolic, Inborn --- Bardet-Biedl Syndrome --- Intellectual disabilities --- Mental deficiency --- Developmental disabilities --- Psychology, Pathological --- People with mental disabilities --- Déficience intellectuelle --- Déficience intellectuelle. --- intellectual disability.